{"id":1507486,"date":"2025-05-30T12:39:34","date_gmt":"2025-05-30T11:39:34","guid":{"rendered":"https:\/\/www.nosoinfo.be\/nosoinfos\/?p=1507486"},"modified":"2025-05-30T12:39:34","modified_gmt":"2025-05-30T11:39:34","slug":"voor-u-gelezen-28","status":"publish","type":"post","link":"https:\/\/www.nosoinfo.be\/nosoinfos\/voor-u-gelezen-28\/?lang=nl","title":{"rendered":"Voor u gelezen"},"content":{"rendered":"

JP Rodriguez Ruiz, Qiang Lin, Ch Lammens, PR Smeesters, S van Kleef-van Koeveringe, V Matheeussen, S Malhotra-Kumar. <\/b><\/p>\n

Increase in bloodstream infections caused by emm1 group A Streptococcus correlates with emergence of toxigenic M1<\/i><\/b>UK<\/i><\/b><\/span>, Belgium, May 2022 to August 2023.<\/i><\/b><\/h2>\n

Eurosurveillance, Vol 28, Issue 36, September 2023
<\/b><\/span><\/p>\n

Many European countries have recently reported upsurges in invasive group A Streptococcus<\/i> (iGAS) infections mainly caused by emm<\/i>1 Streptococcus pyogenes<\/i> specifically the toxigenic M1UK<\/span> lineage. We present the epidemiology of emm<\/i>1 causing iGAS in Belgium during 2018\u2013August 2023 and describe an emergence of the toxigenic M1UK<\/span> lineage in Belgium in mid-2022 that was observed as an increase in bloodstream infections caused by emm<\/i>1 S. pyogenes<\/i> that continued into 2023.
https:\/\/www.eurosurveillance.org\/docserver\/fulltext\/eurosurveillance\/28\/36\/eurosurv-28-36-3.pdf?expires=1731411465&id=id&accname=guest&checksum=A457DA98D76D38CCFC0A8304113901C8<\/a><\/p>\n

S van Kleef \u2013 van Koeveringe, Dr. S De Koster, prof. dr. V Matheeussen<\/b><\/p>\n

National reference centre for invasive <\/i><\/b>\u03b2<\/span>-hemolytic streptococci non groupe B. <\/i><\/b><\/h2>\n

Report 2012-2023\u00a0<\/b><\/p>\n

This report describes the activities performed by the National Reference Centre (NRC) for invasive <\/span>\u03b2<\/span>-hemolytic Streptococci non group B from 2012 until 2023, including species identification via MALDI-TOF MS, detection of virulence genes and\/or macrolide\/tetracycline resistance genes by Whole Genome Sequencing (WGS) and emm typing using Sanger sequencing or WGS. This report aims to follow up on the epidemiological trends of invasive <\/span>\u03b2<\/span>-hemolytic streptococci over the past decade, highlighting changes in strain distribution, resistance patterns, and the emergence of new virulence factors. <\/span>Streptococcus pyogenes<\/i> (group A streptococcus, GAS) and Streptococcus dysgalactiae (groups C and G streptococci, GCS and GGS) are capable of causing a wide range of infections. These range from superficial infections such as pharyngitis and impetigo, to severe invasive infections like necrotizing fasciitis, bacteremia, and streptococcal toxic shock syndrome. Invasive infections are associated with significant morbidity and mortality, particularly in vulnerable populations.The virulence of these organisms is largely attributed to a variety of factors, including the M proteins (encoded by the emm or stG genes), which help the bacteria evade the immune system. Given the significant burden of invasive streptococcal infections, vaccine development has been a subject of interest, particularly targeting the M protein due to its role in pathogenesis and surface accessibility. Although no vaccine is currently available, ongoing research explores the potential for vaccine strategies to prevent infections by <\/span>S. pyogenes<\/i> and <\/span>S. dysgalactiae<\/i>..<\/span><\/p>\n

https:\/\/www.sciensano.be\/sites\/default\/files\/report_2012-2023_streptococci_v1.0.pdf<\/span><\/a><\/p>\n

L Cornelissen\u00a0 <\/span>S van Kleef-van Koeveringen , V Matheeussen <\/b><\/p>\n

Epidemiologische surveillance van invasieve infecties veroorzaakt door groep A streptokokken S. pyogenes – 2017 tot 2023 <\/i><\/b><\/h2>\n

Sciensano, epidemiologisch rapport 2017-2023, invasieve infecties veroorzaakt door groep A streptokokken<\/b><\/p>\n

Hoofdpunten: <\/b><\/span><\/p>\n

\u2022 Alle gegevensbronnen (peillabo\u2019s, Nationaal Referentiecentrum en verplichte meldingen) geven dezelfde globale trends aan: een lage frequentie van iGAS tijdens de pandemische jaren 2020-2021 en een sterke stijging vanaf eind 2022, met hele hoge aantallen in 2023. \u2022 De piek van het aantal gerapporteerde iGAS gevallen lag rond de jaarwisseling 2022- 2023: in december \u201822 volgens de cijfers van het Nationaal Referentiecentrum (NRC) en de peillaboratoria, in januari \u201823 volgens de cijfers van de verplichte meldingen (VM). \u2022 Hoe groot de relatieve toename juist was ten opzichte van vorige jaren is moeilijk te zeggen wegens beperkingen in de verschillende gegevensbronnen. \u2022 Het meest voorkomende genotype tijdens de piek van 2022-2023 was M1. \u2022 Het is onduidelijk waardoor de piek juist veroorzaakt werd, vermoedelijk speelt een combinatie van factoren een rol: lage circulatie tijdens de pandemie waardoor verminderde opbouw van immuniteit bij jonge kinderen, plots meer nauwe contacten en meer andere virale infecties (die een risicofactor vormen voor iGAS) na opheffen hygi\u00ebnische maatregelen en mogelijk ook een meer virulent genotype. \u2022 De leeftijdsgroepen die het meest getroffen worden, zijn kinderen onder de 5 jaar en volwassenen ouder dan 65 jaar. \u2022 Het betreft ernstige infecties die bijna steeds een ziekenhuisopname vereisen en gepaard gaan met een hoge mortaliteit. Exacte cijfers in verband met mortaliteit zijn er echter niet omwille van problemen met het coderen van de uitkomst (voor de overlijdenscertificaten en minimale ziekenhuisgegevens), registratie op moment van de acute infectie zonder opvolging in de tijd (NRC gegevens), of een beperkte dekkingsgraad (verplichte meldingen)<\/span><\/p>\n

Nicolas Yin, Charlotte Michel, Nadia Makki, Ariane Deplano, Alisha Milis, Benoit Prevost, Veronique Yvette Miendje-Deyi, Marie Hallin, Delphine Martiny, National reference centre for Staphylococcus aureus<\/i>.<\/b><\/span><\/p>\n

Emergence and spread of a mupirocin-resistant variant of the European epidemic fusidic acid-resistant impetigo clone of Staphylococcus aureus, Belgium, 2013 to 2023<\/i><\/b><\/span><\/h2>\n

Eurosurveillance, 29, 19, May 2024<\/b><\/p>\n

Background
<\/b>Antimicrobial resistance to mupirocin and fusidic acid, which are used for treatment of skin infections caused by Staphylococcus aureus<\/i>, is of concern.<\/p>\n

Aim
<\/b>To investigate resistance to fusidic acid and mupirocin in meticillin-susceptible S. aureus<\/i> (MSSA) from community-acquired skin and soft tissue infections (SSTIs) in Belgium.<\/p>\n

Methods
<\/b>We collected 2013\u20132023 data on fusidic acid and mupirocin resistance in SSTI-associated MSSA from two large Belgian laboratories. Resistant MSSA isolates sent to the Belgian Staphylococci Reference Centre were spa-typed and analysed for the presence of the eta and etb virulence genes and the mupA resistance gene. In addition, we whole genome sequenced MSSA isolates collected between October 2021 and September 2023. <\/b><\/p>\n

Results
<\/b>Mupirocin resistance increased between 2013 and 2023 from 0.5-1.5% to 1.7-5.6%. Between 2018 and 2023, 91.4% (64\/70) of mupirocin-resistant isolates were co-resistant to fusidic acid. By September 2023, between 8.9% (15\/168) and 10.1% (11\/109) of children isolates from the two laboratories were co-resistant. Of the 33 sequenced isolates, 29 were sequence type 121, clonal and more distantly related to the European epidemic fusidic acid-resistant impetigo clone (EEFIC) observed in Belgium in 2020. These isolates carried the mupA and fusB genes conferring resistance to mupirocin and fusidic acid, respectively, and the eta and etb virulence genes.<\/p>\n

Conclusion
<\/b>We highlight the spread of a mupirocinresistant EEFIC in children, with a seasonal trend for the third quarter of the year. This is of concern because this variant is resistant to the two main topical antibiotics used to treat impetigo in Belgium.<\/p>\n

\u00a0<\/p>\n

Ariane Deplano, Marie Hallin, Natalia Bustos Sierra, Charlotte Michel, , Benoit Prevos, Delphine Martiny and Nicolas Yin<\/b><\/span><\/p>\n

Persistence of the Staphylococcus aureus epidemic European fusidic acid-resistant impetigo clone (EEFIC) in Belgium.<\/i><\/b><\/span><\/h2>\n

J Antimicrob Chemother 2023; 78: 2061\u20132065<\/b><\/p>\n

Objectives
<\/b>In August 2018, a public health alert was issued in Belgium regarding clusters of impetigo cases caused by the epidemic European fusidic acid-resistant impetigo clone (EEFIC) of <\/span>Staphylococcus aureus<\/i>. As a result, the Belgian national reference centre (NRC) was commissioned to update the epidemiology of S. aureus causing community-onset skin and soft tissues infection (CO-SSTI) to assess the proportion of EEFIC among them.<\/span><\/p>\n

Methods<\/b><\/p>\n

For 1 year, Belgian clinical laboratories were asked to send their first three <\/span>S. aureus<\/i> isolated from CO-SSTI each month. Isolates were tested for antimicrobial susceptibility to oxacillin, mupirocin and fusidic acid.
<\/span>Resistant isolates were also spa typed and tested for the presence of the genes encoding the Panton\u2013Valentine leucocidin, the toxic shock syndrome toxin and the exfoliatins A and B. MLST clonal complexes werededuced from the spa types.<\/span><\/p>\n

Results
<\/b>Among the 518 <\/span>S. aureus<\/i> strains analysed, 487 (94.0%) were susceptible to oxacillin. Of these, 79(16.2%) were resistant to fusidic acid, of which 38 (48.1%) belonged to the EEFIC. EEFIC isolates were mostlyisolated from young patients with impetigo and showed a seasonal late summer peak.<\/span><\/p>\n

Conclusions
<\/b>These results suggest the persistence of EEFIC in Belgium. Furthermore, its prevalence may lead toreconsideration of the treatment guidelines for impetigo.
<\/span>The primary risk assessment of the RAG (risk assessment group) concerning a cluster of fusidic acid-resistant <\/span>Staphylococcus aureus<\/i> in Flanders (Turnhout) can be found on the Sciensano website through the following link :<\/span><\/p>\n

https:\/\/www.sciensano.be\/sites\/default\/files\/pra_impetigo_09042019_v2.1_1.pdf<\/span><\/a><\/p>\n

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JP Rodriguez Ruiz, Qiang Lin, Ch Lammens, PR Smeesters, S van Kleef-van Koeveringe, V Matheeussen, S Malhotra-Kumar. Increase in bloodstream infections caused by emm1 group A Streptococcus correlates with emergence of toxigenic M1UK, Belgium, May 2022 to August 2023. Eurosurveillance, Vol 28, Issue 36, September 2023 Many European countries have recently reported upsurges in invasive […]<\/p>\n","protected":false},"author":2,"featured_media":202,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1507486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/posts\/1507486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/comments?post=1507486"}],"version-history":[{"count":1,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/posts\/1507486\/revisions"}],"predecessor-version":[{"id":1507735,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/posts\/1507486\/revisions\/1507735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/media\/202"}],"wp:attachment":[{"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/media?parent=1507486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/categories?post=1507486"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nosoinfo.be\/nosoinfos\/wp-json\/wp\/v2\/tags?post=1507486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}